Adverse events that may occur with methotrexate include rash, nausea, mucositis, diarrhea, bone marrow suppression, infections, pneumonitis, increased liver enzyme levels, and liver fibrosis or cirrhosis
Following the therapy was a consistent counteraction of early and full multiorgan failure (and heart failure, in particular) and thrombosis of the described occlusion/occlusion-like syndrome [66,71,72,73,74,75,76,77,78,79,80,81,82], peripherally and centrally, and thereby, counteraction of the later isoprenaline-infarction and isoprenaline-reinfarction [79]
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