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[108] The latest generation of e-cigarettes, "pod products", such as Juul, have the highest nicotine content (59 mg/mL), in protonated salt, rather than the free-base nicotine form found in earlier generations, which makes it easier for less experienced users to inhale

The male reproductive system is known to be highly sensitive to many chemicals and drugs which have been found to pose adverse effects on male reproductive capacity under certain conditions (4)

For females, the tobacco-attributable age-standardized DALY rates decreased by 60.67%, from 2749.54 (95% UI = 2098.473482.49) in 1990 to 1081.26 (95% UI = 899.621271.70) in 2017, whereas for males, the rates decreased by 32.92%, from 7843.74 (95% UI = 7106.978636.20) in 1990 to 5261.67 (95% UI = 4878.515684.44) in 2017