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A preclinical pilot study in human patients with chronic pain episodes found, that DSIP significantly reduced pain perception, also improved mood by reduction of depressive states, and that it may potentially be of interest for research into physiological addiction on pain medications, as it was observed to reduce withdrawal symptoms that occurs after discontinuation of long-term analgesic treatment

Bashir S, Banday M, Qadri O et al (2021) The molecular mechanism and functional diversity of UPR signaling sensor IRE1