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Managing stress is equally important, as chronic stress increases cortisol levels, which can accelerate collagen breakdown and deplete glutathione stores

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6 Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA

We selected pAcF as the handles for constructing conjugates instead of other chemistry such as azide mediated click chemistry as the cyclopropane-tetrazine ligation employed in the pAcF system demonstrates superior bioorthogonality compared to azide-alkyne cycloadditions, effectively minimizing off-target reactions in complex cellular environments