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The specific amount of weight you might lose from Zepbound is uncertain, but significant weight loss ranging from 35.5 lb (16.1 kg) to 52.0 lb (23.6 kg) was observed in the 72-week SURMOUNT-1 clinical trial, which compared different Zepbound (tirzepatide) doses to a placebo (inactive treatment)

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People with stomach issues might do better with sublingual or injectable forms

A combined approach is often pursued because its believed to support multiple recovery needs at onceparticularly when someone is dealing with both pain/inflammation and slow tissue remodeling