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As noted, the Wnt/-catenin pathway is a genuine master switch for anagen: stabilizing -catenin in dermal papilla cells accelerates hair growth in experimental models, and the pathways activity distinguishes hair-inducing from non-inducing papilla cells

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Acting on two complementary points of the same axis, the two compounds are studied together for a larger, cleaner GH pulse than either produces alone with Ipamorelin chosen specifically because it raises GH with minimal spillover onto cortisol (the stress hormone) or prolactin