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A large systematic review that examined 8 studies (910 women) found that NAC treatment (either alone or in combination with metformin a diabetic drug commonly used in PCOS) notably boosted pregnancy success rates ( 13 )

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Histopathological evaluation revealed hepatocyte hypertrophy, vacuolar and fatty degeneration, necrosis, and inflammatory cell infiltration, consistent with oxidative stress-induced cytotoxicity