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Nicotine constricts blood vessels diminishing blood flow, which, according to a January 2003 study, may account for smokers having thicker gum tissues

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for the same reason that the tobacco age should be: protecting the health of young people and helping them avoid terrible decisions that they and their families will regret for decades to come

Study outcomes The primary outcome was the comparative bioavailability of nicotine from the Test and Reference products, as assessed by the maximum observed concentration of nicotine (C max ) occurring at time T max , and the area under the plasma concentrationtime curve calculated from 0 min to the time of the last measurement (AUC 0-T )