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Advances in the understanding of gut hormone physiology particularly their role in appetite regulation, metabolism, and glucose homeostasis - have driven the development of glucagon-like peptide 1 (GLP-1) receptor agonists (RAs) as effective and safe treatments for type 2 diabetes (T2D) and obesity

Despite some differences between studies, neurogenesis is clearly impacted in this model with up to a 63% decrease in hippocampal NSC proliferation as early as age 4 months in females, and little capacity to form new neurons by 12 months

Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy

Despite extensive research illustrating their potential as drug delivery systems, clinical translation continues to pose challenges due to low extraction purity and potential safety concerns [158]