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In the context of PCOS, endothelial dysfunction is welldocumented: studies consistently show reduced flowmediated dilation (FMD), elevated soluble ICAM1 and VCAM1, and increased endothelin1 levels compared with matched controls [84]

Chen Y-H, Yang S-F, Yang C-K, Tsai H-D, Chen T-H, Chou M, Hsiao Y-H (2021) Metformin induces apoptosis and inhibits migration by activating the AMPK/p53 axis and suppressing PI3K/AKT signaling in human cervical cancer cells