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Under stimulation by lipopolysaccharide (LPS) and interferon- (IFN-), macrophages adopt the M1 phenotype ( 3 Macrophage metabolic states and tumor function Macrophage polarization is tightly governed by distinct metabolic programs that determine their effector functions within the tumor microenvironment ( 3.1 Oncogenic functions of tumor-associated macrophages Tumor-associated macrophages (TAMs) represent macrophages recruited and reprogrammed by the tumor microenvironment (TME), exhibiting distinct functional differences from conventional immune macrophages

doi: 10.1016/j.cellimm.2021.104286 76 ChingMMReaderJFultonAM

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LOX-1 has been reported to be expressed in endothelial cells, monocyte/macrophages, platelets, and vascular smooth muscle cells (VSMCs) as well as in renal, pulmonary and neuronal tissues