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Statements Data availability statement The original contributions presented in the study are included in the article/supplementary material, further inquiries can be directed to the corresponding author

Consequently, the membrane permeability in all cellular compartments (mitochondria, endoplasmic reticulum and plasma membrane) is lowered and generalized hepatic damage occurs that is characterized by inflammation, fibrosis and cirrhosis

FOXO4-DRI shows potential as a treatment targeting the senescence and apoptosis resistance, and holds promise as an approach to prevent the aggressiveness and relapse of keloids

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