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Investigators are particularly interested in determining the mechanisms by which effects observed in murine models relate to broader mammalian metabolic regulation, and whether different experimental conditions (young vs aged models, healthy vs metabolically compromised states) show differential responses to NNMT inhibition

An alternative explanation is that tryptophan-derived metabolites contribute to IDO-mediated T cell inhibition

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Haghiri, R., Mashayekhi, F., Bidabadi, E