Ji E-S, Lee J-M, Kim T-W, Kim Y-M, Kim Y-S, Kim K
Hepatocytes possess highly efficient counter-regulatory systems against oxidative effects such as cytochrome systems (CYP) P450, either by endogenous or exogenous substances, enzymes such as glutathione S transferase, the flow-through transporters, and molecules that contain thiol, such as Glutathione or Thioredoxin [68]
Hence, it has been proposed that the neurological symptoms present in the most severely affected ACAD9-deficient patients could be attributed to a deficiency in brain FAO
Met-mediated AMPK activation and inhibition of mTOR activity regulate autophagy flux, inhibit NF-B signal transduction and production of inflammatory cytokines, and reduce inflammation during experimentally induced arthritis [145, 146]