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The resulting acyl-phosphate intermediate undergoes nucleophilic attack by the -amino group of cysteine, which may be activated by an active site glutamate

Nasal Spray Seen as Easy and Effective Way to Deliver Glutathione, a Parkinsons Therapy Written by | A pilot study found that a nasal spray may be a promising and quickly effective way of delivering glutathione (GSH), and of increasing GSH levels in the brain of Parkinsons disease (PD) patients

These contain an N-terminal Trx-like domain and three C-terminal monothiol Grxs domains [141]