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They are found in three isoforms and amongst them SOD1 (Cu/Zn-SOD), a predominant oxygen radical scavenger, is localized in the cytoplasm, mitochondrial intermembrane space, nucleus, and lysosomes, whereas SOD2 (Mn-SOD) and SOD3 (Cu/Zn-SOD) are localized in the mitochondrion and extracellular matrix respectively [81, 82]

Ceramide-mediated orchestration of oxidative stress response through filopodia-derived small extracellular vesicles

Graefes Arch Clin Exp Ophthalmol 241(4):321326 Jeong H et al (2020) Sustained nitric oxide-providing small molecule and precise release behavior study for glaucoma treatment