glutathione s transferase mechanism The role of glutathione-S-transferase in anti-cancer drug resistance Insights into the Catalytic Mechanism

10.1126/science.adi7342 46 WangW.LiX.LeeM.JunS.AzizK

Tesofensine (500mcg) is a weight loss compound that works by blocking the reuptake of dopamine, serotonin, and norepinephrine, helping to suppress appetite and reduce food cravings

Likewise, glucosinolate metabolites, particularly sulforaphane, may exert a beneficial effect on neurological and psychiatric conditions, such as depression, schizophrenia, autism, Alzheimers disease, and multiple sclerosis

Because we found this transporter earlier and knew how to block the entry of glutathione, we already had the tools necessary to investigate its role in cancer metastasis, he says