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FIGURE 2 3 Redox dysregulation in disease states 3.1 GSH in peripheral immune cell infiltration Several studies indicate that neuroinflammatory changes associated with neurodegeneration compromise the BBB or its function by disrupting transport systems, facilitating the infiltration of immune cells, and influencing the BBBs role as a signaling interface

[6,7] L'intrt d'associer le glutathion la vitamine C Compte tenu du lien troit entre glutathion et vitamine C dans le cycle de recyclage cellulaire, certains chercheurs se sont intresss leur association

Concurrently, ROS activate immune cells and stimulate lipid mediator generation, establishing a self-perpetuating inflammation loop through NF-B/JAK-STAT signaling [402]

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