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The 2024 NICE Guideline NG239 from the United Kingdoms National Institute for Health and Care Excellence similarly distinguishes between patients who can be managed with oral therapy and those who require intramuscular treatment

10.1093/humupd/dmi012 48 GowenA.ShahjinF.ChandS.OdegaardK

The overall evidence is in favour of the use of NAC in COPD, and NAC is licensed in many countries as a mucolytic for patients with COPD and other airway diseases, such as cystic fibrosis

Clin Biochem 42:949957 Chez MG, Buchanan CP, Aimonovitch MC, Becker M, Schaefer K, Black C, Komen J (2002) Double-blind, placebo-controlled study of L-carnosine supplementation in children with autistic spectrum disorders