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The next studies revealed particular relationships with sphincter function [197], free-radical-induced injuries [197], bleeding [144,187,192], non-specific and specific NSAID-induced lesions [201], general anesthesia (thiopental) [202] and local anesthesia (lidocaine) [203] induced disturbances, and rat models that resemble schizophrenia-positive symptoms and negative symptoms [171,200]

Others may have concerns about potential effects on healing

In people whose vitamin B 12 deficiency is related to overgrowth of intestinal bacteria, treatment with oral antibiotics such as tetracycline (sold under several brand names) may stop bacterial overgrowth and allow the absorption of vitamin B 12 to return to normal