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Aside from complex interactions among the multitudes of single nucleotide polymorphisms incorporated into genetic networks, also known as genetic epistasis, structural genomic variations such as copy number variants and epigenetic variation all seem to play a role in the transmission of bipolar illness (20, 30, 31)

Garca, J

and the same clinical dose of the TNF- antibody used in rheumatoid arthritis has a definite effect on bronchial asthma, but has not been confirmed in COPD