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As part of general disease processes, the UPS regulates renal fibrosis and renal inflammation, affects acute kidney injury and is involved in chronic kidney disease-associated muscle atrophy

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GMS Interdisciplinary Plastic and Reconstructive Surgery DGPW, 12 , Doc09

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In particular, it can reprogram the tumor microenvironment, converting it from a noninflamed cold tumor to an inflamed hot tumor

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Lancet 377 , 21812192 (2011)

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