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[25] In human cells with mutant WRN, NAD+ repletion restored normal mitophagy, improved fat metabolism, decreased mitochondrial oxidative stress, and enhanced mitochondrial quality

For example, in one clinical trial, hypertensive TT subjects taking 1.6 mg/day of riboflavin (in addition to normal antihypertensive medication) over 16 weeks experienced an average decrease of 5.6 mm/Hg in systolic blood pressure compared to those taking a placebo

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