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10.1016/j.bjp.2016.01.012 123 RazzoliM.DomeniciE.CarboniL.RantamakiT.LindholmJ.CastrenE.et al (2011)

Elevated levels of liver enzymes gamma-glutamyl transpeptidase (GGT), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) can indicate liver damage, as can elevated serum bilirubin (a breakdown product of the red blood cell component hemoglobin normally cleared by a healthy liver)

By disrupting this interaction, FOXO4-DRI has been studied for its ability to selectively induce programmed cell death in senescent cells while leaving healthy cells unaffected in preclinical research models

TB-500 also demonstrates anti-inflammatory properties and inhibits osteoclast differentiation, the cells responsible for bone resorption