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The hormone promotes gluconeogenesis (glucose production) in the liver and reduces glucose uptake in peripheral tissues, creating an insulin-resistant state

WellsJMBrummerRJDerrienMMacDonaldTTTroostFCaniPDet al

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A phase I trial involving 40 patients with relapsed/refractory HL that the combination of Vorinostat (300 mg/day orally) with sirolimus (4 mg/day orally, n=22) or Everolimus (5-10 mg/day dose escalation, n=18) yielded ORR of 55% and 33%, respectively, with a median progression-free survival (PFS) of 5.8 months, suggesting synergistic efficacy of HDACi combined with mTOR inhibitors (90)