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The transition from the lipid environment of the BBB endothelial cell membrane to the aqueous interstitial fluid of the brains extracellular space necessitates further consideration of a drug and its delivery vehicles physicochemical properties, including size, surface charge, shape, and molecular weight (Sykova and Nicholson, 2008

Research suggests that calcium deficiency may be a common concern for women with PCOS, although the exact relationship between calcium status and insulin resistance remains uncertain [141]

GSH is thought to be the most important endogenous non-enzymatic antioxidant (Kurutas 2016) and hence may be a key target in future treatments for MDD