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Combined treatment with DFX-DFO rapidly reduces myocardial and hepatic iron concentrations and significantly improves myocardial function and ejection fraction in patients with severe transfusional myocardial siderosis (NCT01254227)

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A loading period usually lasts 3 to 6 months before full effects are observed

When pathogen-derived or endogenous ligands are detected by injured cells, pattern recognition receptors (PRRs), which are produced by astrocytes and microglia, start the innate immune response [66]