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Paul was always searching not for fame or recognition, but for ways to understand people and help them see themselves more clearly, says Sylvee, who met Crockett in Shoshone in 1972, three years after the events at Barker Ranch

Introduction The current tobacco product marketplace is highly diverse and has been evolving over the past decade with the emergence of novel tobacco and nicotine products including electronic cigarettes, heated tobacco products, and oral nicotine pouches (ONPs) ( Tobacco harm reduction (THR) is a public health risk mitigation strategy aimed at reducing the health burden associated with cigarette smoking ( will focus on a regulatory framework that focuses on and supports innovation to promote harm reduction ( Oral nicotine pouches (ONPs) are an emerging category of nicotine products that contain pharmaceutical-grade nicotine, but no tobacco leaf ( Combustible cigarettes exhibit a high degree of abuse liability (AL), a term synonymous with dependence potential ( The AL of a novel nicotine-containing tobacco product is a composite measure based predominantly on the pharmacokinetic (PK) and subjective effects associated with the use of that product ( Materials and methods Study design In three separate randomized, open-label, crossover, in-clinic confinement studies, subjective effects and nicotine uptake of Velo ONPs were evaluated among adult smokers