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Autocrine and paracrine role of IGF-1 in breast cancer In contrast to the serum IGF-1 expression findings described above, increased IGF-1 mRNA levels within tissue samples may confer a favorable outcome and have been associated with increased disease-free survival (DFS) in patients with diagnosed estrogen receptor positive (ER + ) breast cancer [44]

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However, inhibition of endonuclease activity of APE1, rather than REDOX function, could interact with NPM1 to trigger p53-mediated effects on colon cancer cell metabolism and improve its sensitivity to targeted drugs [22]

doi: 10.1152/ajpgi.00339.2001