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As presented in Table 2, this pathway was not mediated by CPD, given that the association between exposure and outcome remained significant after adjusting for the potential mediator (CPD)

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Consistent with our findings with ECIG-flavor-2 in the bronchial model, decreased SCGB1A1, increased SLPI, and increased PI3 levels were detected in the sputum from COPD patients compared to smokers without COPD and/or never smokers 78

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