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Chem Biol Interact 96:87101 Kurtovic J, Riordan SM (2003) Paracetamol-induced hepatotoxicity at recommended dosage

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For this study, researchers looked at the medical data of almost half-a-million people between the ages of 38 and 73, and asked them if they felt more like night owls or early birds

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Although promising, the absence of blinding and placebo control limits the strength of causal inference (Shaaban et al., 2018)

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This suggests that the cellular response to APAP, be it JNK activation, Bax translocation, or induction of the MPTP, can be calibrated to the dose of APAP the cells are exposed to

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