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We also discuss the science of how to define goals and intermediate milestones, overcome obstacles, and effectively track progress

The TME is a complex and multi-layered structure, primarily consisting of cancer cells, cancer-associated fibroblasts (CAFs), cells that suppress the immune system (such as tumor-associated macrophages [TAMs], myeloid-derived suppressor cells [MDSCs], and regulatory T cells), cells that activate the immune system (including natural killer [NK] cells, dendritic cells [DCs], and T cells), and a variety of signaling molecules [33,34,35,36]

If you don't see anything by week 8, the dose is likely too low or the sourcing is suspect