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In some embodiments, the formulations or compositions described herein have a pH between about 5 and about 8, or between about 6 and about 7, or between about 6.5 and about 7, or between about 5.5 and about 7.5, or between about 7.1 and about 7.7, and have a concentration of active pharmaceutical ingredient between about 1 and about 100 mM

While the overall safety profiles of these materials vary, some, like liposomes and polymeric NPs, have been studied extensively and are approved in specific clinical contexts

For example, oligomers of tau, in which SL are restrained but do not show inter-spin interactions, were observed before the formation of mature amyloid aggregates (Pavlova et al., 2016

Rosenberg T, Gal-Ben-Ari S, Dieterich DC, Kreutz MR, Ziv NE, Gundelfinger ED, et al