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Deficiency in vitamin B12 is also associated with disproportionate fetal growth (low muscle mass and excess fat mass), increased insulin resistance, intrauterine growth restriction, and lifelong susceptibility to certain chronic diseases

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Aged mice also have hallmarks of BBB breakdown compared to young mice with increased leakage of IgG into the brain parenchyma, a reduction of the tight junction protein occludin, and a reduction in pericyte coverage and pericyte induced expression of genes in the endothelium [54, 90, 91]

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