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Moreover, a multicentric, double-blind, placebo-controlled, randomized trial that used the same methodology found that in patients who are suffering from stage I or II HNSCC and on radiation therapy while taking 400 IU of -tocopherol daily had a significantly higher incidence of subsequent primary malignancies (60/1000 person-years) compared to those on placebo (25/1000 person-years)

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Metformin , commonly prescribed for type 2 diabetes, can reduce B12 absorption with long-term use