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In several robust trials, a marked decrease in the incidence of acute respiratory disease, ischemic heart disease, hypertension disease, pulmonary fibrosis, coronary artery disease, diabetes mellitus, Alzeimers disease, deforming osteoarthrosis, and osteoporosis was observed as compared to control animals 6

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In one embodiment of the otic formulations or compositions described herein, the otic formulation or composition is provided as a solution formulation composition, also referred to herein as auris-acceptable solution formulation or composition, auris solution formulations or compositions or variations thereof