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A personal dose would need to account for diagnosis, other medicines, allergies, pregnancy status, kidney or liver disease, substance use, and the exact product being used

Biogerontology (NLM) .Read source (2006)

Current research indicates that the cell cycle arrest depends on the activity of cyclin-dependent kinase inhibitors (CDK) p16 and p21, often regulated by the main tumor suppressor protein p53, whose elevated level is frequently used as a marker of senescence detection [21]

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