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Fayad L, Kantarjian H, OBrien S, Beran M, Koller C, Kornblau S, Andreeff M , Estey E, Keating M, Freireich E

Isoliquiritigenin attenuates septic acute kidney injury by regulating ferritinophagy-mediated ferroptosis

The honest accounting of the evidence: while these mechanisms are compelling and the animal data is genuinely encouraging, the absence of human randomized controlled trials for all three compounds means that anyone using them for serious GI conditions should do so as a complement to evidence-based medical care not as a replacement for it