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uncovered that chronic inflammation of the meibomian gland was accompanied by the destruction of mitochondrial structure, especially mitochondrial cristae, which suggests that mitochondrial damage might participate in the inflammatory response mechanism of the meibomian gland

The presence of three chiral centers in the saturated side chain, presenting as either R- or S-configuration, leads to eight different stereoisomers, among which only -tocopherol in its RRR conformation is selectively retained and incorporated into lipoproteins, while non--tocopherol congeners are preferentially metabolized and excreted (Podszun and Frank 2021)

In turn, COX-2 signals for the production of a short-lived signaling molecule called series-2 prostaglandins

So yeah, so that's a history