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That effort, costing $48 million to $60 million each year, has been credited with helping 100,000 Americans quit smoking

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3 Impact of tobacco smoke on enzymatic drug metabolism Tobacco smoke is a complex mixture of polycyclic aromatic hydrocarbons (PAHs), ammonia, aromatic amines, phenols, carbonyls, hydrocyanic acid, and N-nitrosamines (Maideen, 2019)