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Impact of Cerebrovascular Disease on BBB Integrity Cerebrovascular syndromes, including stroke, vascular malformations, vascular dementia, and edema related to post-traumatic epilepsy, are closely linked to BBB dysfunction (Andjelkovic et al., Figure 6)

community and clinical sources describe dermatological monitoring for these changes, especially with long-term use Injection site darkening localized hyperpigmentation Mood changes irritability reported by some during loading Managing nausea: community sources commonly describe beginning at 100-250 mcg, injecting before bed on an empty stomach, using anti-nausea medication (ondansetron) when needed, and escalating the dose gradually

Rosenstock JAMA 2023

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