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The electrolyte imbalances likely arise as a result of damage to the lens cell membranes, especially those of the lens epithelial cells, which play the major role in maintaining the ionic and metabolic homeostasis of the entire lens

Potential Interactions of AOD9604 with Fat Store Accumulation Another potential mechanism related to fat cells, which may be common between AOD9604 and hGH, is the apparent mitigation of acetyl-CoA carboxylase (ACC), an enzyme involved in fatty acid synthesis, thus potentially limiting new adipose tissue accumulation

The four-week hold per step is not arbitrary it matches the interval at which GI adverse events subside as the gut adapts

PubMed Sigalos JT, et al