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Specifically, in secretion-competent INS-1E cells and isolated mouse islets (186), butyrate significantly attenuates IL-1- or IL-1/IFN--induced apoptosis by suppressing endoplasmic reticulum (ER) stress, while reducing the production of nitric oxide (NO) and chemokines (CXCL1, CXCL10) that amplify immune cell infiltration

El-Far M, El-Sayed IH, El-Motwally Ael G, Hashem IA, Bakry N: Tumor necrosis factor-alpha and oxidant status are essential participating factors in unexplained recurrent spontaneous abortions