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NAC activates cystine-glutamate antiport transporters present in astrocytes, leading to the release of glutamate that stimulates extra-synaptic metabotropic receptors (mGluRs), thereby reducing the synaptic release of the neurotransmitter (Baker et al., 2002

This validation design allowed the construction of calibration curves (using the unspiked sample, SA2, and SA3) to accurately quantify the SA1 samples and to verify linearity via the coefficient of determination ( R 2 )

Here, we focus on biomaterials-based ACE2 reinforcement of airway mucus