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Patients describe a profound, unrelenting exhaustion that does not improve with rest and is dramatically worsened by physical or cognitive exertion, a pattern called post-exertional malaise (PEM)

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Moreover, in cases of nerve pain caused by carpal tunnel syndrome and pain associated with knee osteoarthritis, PEA has demonstrated the ability to reduce neuropathic pain and attenuate symptoms in double-blind, placebo-controlled studies