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These medications work through several mechanisms: Slowing gastric emptying : Food stays in your stomach longer, creating extended feelings of fullness Reducing appetite : They act on brain centers that control hunger signals Improving insulin sensitivity : They help your body use insulin more effectively Suppressing glucagon : They prevent your liver from releasing stored glucose into the bloodstream Currently available GLP-1 medications include: Also Read: 11 Essential Facts About Semaglutide The Hidden Long-Term Effects of GLP-1 Medications While the dramatic weight loss and improved blood sugar levels make headlines, several concerning long-term effects deserve more attention: 1