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2 The SNPs would be specifically removed for the analysis in Figure 1A if related to hypertension, diabetes, smoking, obesity, depression, cholesterol, and hard of hearing on AD (26), head trauma, intake of antioxidants, and smoking on ALS (27, 28), caffeine consumption on PD (29)

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Activation of these receptors enhances burst firing in dopaminergic neurons, increases dopamine release in the nucleus accumbens, thereby forming rewarding signals for external stimuli such as nicotine ( 5 , 3 , and 4 subtypes similarly play negative regulatory roles in nicotine uptake and aversive effects (Sheffield et al., 2000)