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Serine/threonine kinase (Akt), also known as protein kinase B, is an enzyme consisting of a PH domain, a kinase catalytic domain, and a regulatory domain that covalently attaches ATP-phosphate groups to the serine/threonine of protein substrates to alter target protein activity

However, overexpression of myo-inositol oxygenase (MIOX) can aggravate cisplatin-induced ferroptosis in the context of AKI by downregulating GPX4 activity, promoting lipid peroxidation and increasing the ferritinophagy rate [172]

Think of BPH as a blocked pipe