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The point from where you start is your production requirement

Research shows that nicotine alone does not cause lung cancer, stroke, or chronic obstructive pulmonary disease (COPD) that are commonly associated with smoking.[12] Rather, the other toxic chemicals and combustion in cigarettes and tobacco are what cause cancer

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Similar results were also observed in a group of current consumers of combustible tobacco products who exhibited a decrease in oxidative stress four months after switching to ENDS use, even when nicotine was still present [132]