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In CD8 + T cells, JHU-083 suppresses glutamine metabolism and glycolysis but upregulates OXPHOS, utilizing extracellular acetate as an alternative fuel to potentiate its anti-tumor effects [15]

52 Because of its potential to cause serious adverse side effects, cyclosporin A is reserved for those with intractable symptoms

4.3 Liver G6PD function in the liver is relevant to systemic immunity, given the livers key role in producing relevant plasma proteins, including acute phase reactants, cytokines, and complement factors ( Figure 1B-5 )